We examined the role of selenium in treating myocardial infarction (MI), a major cause of death worldwide that can lead to serious heart problems. The study focused on how this antioxidant works across different phases of a heart attack, where harmful reactive oxygen species (ROS) play a significant role in worsening the condition.
Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.
Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.
Read More
9
Selenium nanoparticles aid heart recovery
Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation.
We investigated the potential of spherical selenium nanoparticles (SeNPs) to reduce the harmful effects of ischemia/reperfusion injury (I/RI) that often occurs after a heart attack. The study involved intravenous injections of these nanoparticles, which showcased impressive antioxidant and anti-inflammatory properties.
Our findings revealed that SeNPs effectively disrupted the harmful cycle of oxidative stress and inflammation associated with heart damage. They helped protect the heart cells by keeping mitochondrial functions intact and reducing programmed cell death, also known as apoptosis. Furthermore, SeNPs managed to lessen the invasion of inflammatory cells and reduce the release of harmful mediators during I/RI.
In practical terms, when tested in vivo, the selenium nanoparticles significantly improved heart function while reducing both cell death and tissue scarring. This indicates that these nanoparticles could offer a promising new approach to enhance treatments following heart attacks, specifically by focusing on the key pathway of STAT1, which plays a crucial role in mediating injury and inflammation.
Read More
9
Selenium treatment for heart attack
Injectable selenium-containing polymeric hydrogel formulation for effective treatment of myocardial infarction.
We explored an innovative approach to treating heart attacks, specifically looking at how selenium can make a difference. Our study focused on a special injectable hydrogel made from a combination of selenium, polypropylene glycol, and polyethylene glycol. The goal was to see if this formulation could help reduce inflammation and fibrosis after a myocardial infarction (heart attack).
We conducted our research on a mouse model of myocardial infarction, observing the effects of our selenium-containing hydrogel. The results were promising—our formulation demonstrated the ability to promote recovery in heart function. Through various tests, including enzyme-linked immunosorbent assays and tissue analysis, we confirmed that the gel effectively inhibits harmful inflammation and fibrosis that often occur after a heart attack.
Overall, this work highlights the potential of selenium as a beneficial component in therapies for heart attacks and possibly other inflammatory conditions. Our findings suggest that a selenium-infused polymeric hydrogel could be an effective strategy for improving heart health in the aftermath of a myocardial infarction.
Read More
Most Useful Reviews
9
Prevents heart damage
2 people found this helpful
Excellent selenium! It supports the immune system, prevents ageing, and halts inflammatory processes. It strengthens blood vessels, protects the heart from damage, prevents viral mutation, and is crucial for the thyroid gland's function. My husband and I take one tablet for three months, followed by a break. A single can lasts us three months.
Read More
7.5
Heart health improvement
Excellent! Selenium normalises fat metabolism and cholesterol levels in the blood, protects blood vessels and heart muscle from damage, and reduces the likelihood of developing hypertension. It also restores liver and pancreas cells.
Read More
7.5
Well absorbed quality
I choose selenium from this company as it not only normalises fat metabolism and cholesterol levels in the blood, but also protects blood vessels and heart muscle from damage, while reducing the likelihood of hypertension. The brand is well absorbed in the body, of good quality, and has a neutral taste. I recommend it!
We examined the role of selenium in treating myocardial infarction (MI), a major cause of death worldwide that can lead to serious heart problems. The study focused on how this antioxidant works across different phases of a heart attack, where harmful reactive oxygen species (ROS) play a significant role in worsening the condition.
Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.
Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.
Read More
9
Selenium nanoparticles aid heart recovery
Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation.
We investigated the potential of spherical selenium nanoparticles (SeNPs) to reduce the harmful effects of ischemia/reperfusion injury (I/RI) that often occurs after a heart attack. The study involved intravenous injections of these nanoparticles, which showcased impressive antioxidant and anti-inflammatory properties.
Our findings revealed that SeNPs effectively disrupted the harmful cycle of oxidative stress and inflammation associated with heart damage. They helped protect the heart cells by keeping mitochondrial functions intact and reducing programmed cell death, also known as apoptosis. Furthermore, SeNPs managed to lessen the invasion of inflammatory cells and reduce the release of harmful mediators during I/RI.
In practical terms, when tested in vivo, the selenium nanoparticles significantly improved heart function while reducing both cell death and tissue scarring. This indicates that these nanoparticles could offer a promising new approach to enhance treatments following heart attacks, specifically by focusing on the key pathway of STAT1, which plays a crucial role in mediating injury and inflammation.
Read More
9
Selenium's potential in cardiac recovery
Facile fabrication of biocompatible injectable blended polymeric hydrogel with bioactive nanoformulation to improving cardiac tissue regeneration efficiency after myocardial infarction for nursing care potential applications.
We investigated how selenium, specifically in the form of selenium nanoparticles (Se NPs), can play a role in recovering from heart attacks. Our study focused on developing a unique hydrogel that combines Se NPs with a polymer base to improve cardiac repair after acute myocardial infarction (MI).
We explored the effects of the Se NPs on human heart cells and conducted experiments on mice models. The results were promising; the hearts of the treated mice showed a significant improvement with the left ventricular wall thickness increasing from a mere 235.6 micrometers to an impressive 390 micrometers.
Not only did these treatments help thicken the heart walls, but we also saw a remarkable reduction in scar thickness and infarct size when compared to control groups. This suggests that our selenium-infused hydrogel could be a valuable solution to promote heart healing post-MI, paving the way for potentially advanced treatments in the future.
Read More
9
Gold nanocages help heart recovery
L-Arginine-Loaded Gold Nanocages Ameliorate Myocardial Ischemia/Reperfusion Injury by Promoting Nitric Oxide Production and Maintaining Mitochondrial Function.
We explored the potential of a novel treatment involving L-arginine-loaded gold nanocages designed to help with heart attack recovery. This innovative approach aims to tackle the problem of myocardial ischemia/reperfusion injury, a condition that can cause additional damage to the heart after blood flow is restored post-heart attack.
The gold nanocages in this study were enhanced with selenium and targeted towards heart cells, allowing for better absorption and effectiveness. Our tests showed that this treatment reduced cell damage and improved cell health during oxygen and glucose deprivation, which is crucial during heart attacks.
Furthermore, we observed that this treatment can help maintain mitochondrial function, leading to better energy production in heart cells. By preventing harmful oxidative reactions, it helps preserve nitric oxide, a vital molecule that supports heart health.
Ultimately, the results indicated that this approach could improve overall heart function and reduce cell death in heart tissue. The findings are promising and suggest a new pathway for effective heart attack treatments while ensuring safe and biocompatible use in living organisms.
Read More
9
Selenium treatment for heart attack
Injectable selenium-containing polymeric hydrogel formulation for effective treatment of myocardial infarction.
We explored an innovative approach to treating heart attacks, specifically looking at how selenium can make a difference. Our study focused on a special injectable hydrogel made from a combination of selenium, polypropylene glycol, and polyethylene glycol. The goal was to see if this formulation could help reduce inflammation and fibrosis after a myocardial infarction (heart attack).
We conducted our research on a mouse model of myocardial infarction, observing the effects of our selenium-containing hydrogel. The results were promising—our formulation demonstrated the ability to promote recovery in heart function. Through various tests, including enzyme-linked immunosorbent assays and tissue analysis, we confirmed that the gel effectively inhibits harmful inflammation and fibrosis that often occur after a heart attack.
Overall, this work highlights the potential of selenium as a beneficial component in therapies for heart attacks and possibly other inflammatory conditions. Our findings suggest that a selenium-infused polymeric hydrogel could be an effective strategy for improving heart health in the aftermath of a myocardial infarction.
Excellent selenium! It supports the immune system, prevents ageing, and halts inflammatory processes. It strengthens blood vessels, protects the heart from damage, prevents viral mutation, and is crucial for the thyroid gland's function. My husband and I take one tablet for three months, followed by a break. A single can lasts us three months.
Read More
7.5
Heart health improvement
Excellent! Selenium normalises fat metabolism and cholesterol levels in the blood, protects blood vessels and heart muscle from damage, and reduces the likelihood of developing hypertension. It also restores liver and pancreas cells.
Read More
7.5
Well absorbed quality
I choose selenium from this company as it not only normalises fat metabolism and cholesterol levels in the blood, but also protects blood vessels and heart muscle from damage, while reducing the likelihood of hypertension. The brand is well absorbed in the body, of good quality, and has a neutral taste. I recommend it!
Read More
7.5
Good for heart
A very good product, beneficial for the heart, reasonably priced with good effects!
Read More
Frequently Asked Questions
A heart attack, also known as myocardial infarction, occurs when blood flow to a part of the heart is blocked, often by a blood clot. This interruption can damage or destroy part of the heart muscle, leading to serious health complications or death if not treated promptly. Common symptoms include chest pain, shortness of breath, nausea, and lightheadedness. Risk factors include high blood pressure, high cholesterol, smoking, diabetes, and a sedentary lifestyle.
Preventing a heart attack largely revolves around maintaining a heart-healthy lifestyle. Regular exercise, a balanced diet rich in fruits, vegetables, whole grains, and lean proteins, along with managing stress, can significantly lower the risk. Furthermore, understanding your personal risk factors and engaging with healthcare professionals for regular check-ups can be crucial in both prevention and early detection. If you suspect someone is having a heart attack, it's important to call emergency services immediately, as timely treatment is vital for survival and recovery.
Selenium is a powerful and widely used open-source tool designed for automating web applications for testing purposes. It enables developers and testers to write code in various programming languages such as Java, Python, C#, and Ruby to simulate user interactions with a web browser. Selenium's flexibility allows users to create complex test scenarios that mimic real-world user behaviors, making it an essential tool for ensuring web application functionality and performance.
In addition to its core functionalities, Selenium consists of several components, including Selenium WebDriver for automating browsers, Selenium Grid for running tests across multiple machines and environments in parallel, and Selenium IDE for record-and-playback test creation. Its compatibility with multiple browser types—such as Chrome, Firefox, Safari, and Edge—makes it a versatile choice for automated testing, catering to a wide range of projects and team needs. For anyone involved in web development or quality assurance, understanding and utilizing Selenium can significantly improve testing efficiency and reliability.
Based on user reviews, the time it takes to see results from selenium supplements can vary. Some users report that after taking the supplement consistently for about three months, they start to notice positive effects on heart health and other benefits, such as improved cholesterol levels and reduced inflammation (Read Review). Additionally, the overall sentiment from reviews suggests that many customers feel the product is effective within a similar timeframe, emphasizing its role in normalizing fat metabolism and protecting heart muscles (Read Review).
While individual experiences may differ, users generally indicate a noticeable improvement in cardiovascular health after a sustained period of use. Therefore, if you are considering selenium for heart support, aiming for at least a three-month commitment seems to be a common recommendation among reviewers, as it allows sufficient time for the body to respond to the supplement's effects (Read Review).
The current body of scientific research offers promising insights into the potential benefits of selenium supplementation for heart attack recovery. One study demonstrated that selenium nanoparticles significantly improved heart function and reduced cell death and tissue scarring post-heart attack, indicating a beneficial role in mitigating damage from ischemia/reperfusion injury [1]. Additionally, other research reported that selenium, particularly when combined with the treatment pentoxifylline, enhanced heart healing by improving function and promoting new blood vessel formation after a myocardial infarction [2].
However, while several studies show correlations between selenium levels and heart health, it's crucial to emphasize that not all findings unequivocally support selenium treatment as a direct remedy for heart attack recovery. For instance, although lower selenium levels were linked to increased cardiac injury markers, establishing definitive treatment outcomes requires further research [8]. Ultimately, while selenium presents a potential avenue for enhancing heart health and recovery, more comprehensive studies are necessary to clarify its clinical effectiveness and optimal application in heart attack scenarios.
Users report a variety of improvements in their symptoms after taking selenium supplements. Many highlight enhanced immune support and a reduction in inflammation, suggesting that the product plays a key role in bolstering overall health (Read Review). Furthermore, several reviewers note significant benefits for cardiovascular health, such as normalized fat metabolism and cholesterol levels, which ultimately protect the heart and blood vessels from damage (Read Review).
Many users also express satisfaction with the supplement's ability to reduce the risk of hypertension, signifying a multi-faceted approach to heart health (Read Review). Overall, while individual results may vary, the consensus among reviews suggests that consistent use can lead to a noticeable improvement in cardiovascular and general health, making this supplement a worthwhile consideration for those seeking to enhance their well-being.
Based on user reviews, there is a consensus that Selenium can be beneficial for heart health, with many users reporting positive results. One reviewer specifically mentioned taking one tablet for three months, followed by a break, indicating a dosage regimen that worked well for them and their spouse Read Review. Additionally, another user emphasized that Selenium not only normalizes fat metabolism and cholesterol levels but also protects blood vessels and heart muscle from damage Read Review.
Though specific dosing amounts were not universally specified across the reviews, the general theme suggests that consistent use over a period of time can yield significant benefits. Users appreciate the product’s quality and absorption, which adds to the effectiveness of whatever dosage is being taken Read Review. Ultimately, while specific dosage recommendations may vary, the overall sentiment leans towards regular consumption leading to favorable health outcomes for the heart.
9
Prevents heart damage
2 people found this helpful
Excellent selenium! It supports the immune system, prevents ageing, and halts inflammatory processes. It strengthens blood vessels, protects the heart from damage, prevents viral mutation, and is crucial for the thyroid gland's function. My husband and I take one tablet for three months, followed by a break. A single can lasts us three months.
7.5
Heart health improvement
Excellent! Selenium normalises fat metabolism and cholesterol levels in the blood, protects blood vessels and heart muscle from damage, and reduces the likelihood of developing hypertension. It also restores liver and pancreas cells.
7.5
Good for heart
A very good product, beneficial for the heart, reasonably priced with good effects!
7.5
Well absorbed quality
I choose selenium from this company as it not only normalises fat metabolism and cholesterol levels in the blood, but also protects blood vessels and heart muscle from damage, while reducing the likelihood of hypertension. The brand is well absorbed in the body, of good quality, and has a neutral taste. I recommend it!
9
Selenium nanoparticles aid heart recovery
Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation.
We investigated the potential of spherical selenium nanoparticles (SeNPs) to reduce the harmful effects of ischemia/reperfusion injury (I/RI) that often occurs after a heart attack. The study involved intravenous injections of these nanoparticles, which showcased impressive antioxidant and anti-inflammatory properties.
Our findings revealed that SeNPs effectively disrupted the harmful cycle of oxidative stress and inflammation associated with heart damage. They helped protect the heart cells by keeping mitochondrial functions intact and reducing programmed cell death, also known as apoptosis. Furthermore, SeNPs managed to lessen the invasion of inflammatory cells and reduce the release of harmful mediators during I/RI.
In practical terms, when tested in vivo, the selenium nanoparticles significantly improved heart function while reducing both cell death and tissue scarring. This indicates that these nanoparticles could offer a promising new approach to enhance treatments following heart attacks, specifically by focusing on the key pathway of STAT1, which plays a crucial role in mediating injury and inflammation.
8
Selenium enhances heart recovery
Enhancement of cardiac angiogenesis in a myocardial infarction rat model using selenium alone and in combination with PTXF: the role of Akt/HIF-1α signaling pathway.
We explored the effects of selenium (Se) on heart health, specifically its ability to promote healing after a heart attack, also known as myocardial infarction (MI). Our research was conducted using a rat model where we induced heart attacks using a chemical agent called isoprenaline (ISP). After one week, we administered selenium either by itself or combined with another treatment, pentoxifylline (PTXF).
We found that selenium, both alone and with PTXF, showed promising potential in reducing damage caused by heart attacks. The treatment led to improvements in heart function indicators and enhanced angiogenesis, which is the formation of new blood vessels—critical for healing. Importantly, the combination of selenium and PTXF was more effective than using either treatment separately.
Our study highlights the beneficial effects of selenium on cardiac health and suggests a new avenue for treatment strategies following heart attacks. These results point to selenium, especially combined with PTXF, as a potentially impactful option for further investigation in clinical settings.
4
Selenium effects on heart injury
CORRELATION OF CARDIAC BIOMARKERS WITH THE LEVELS OF SELENIUM AND ANTIOXIDANT ENZYMES IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND A HISTORY OF HYPERTENSION.
We explored the connection between selenium levels, antioxidant enzymes, and cardiac injury markers in patients who experienced a non-ST segment elevation myocardial infarction, particularly focusing on those with a history of hypertension. Our study involved 72 patients—42 with hypertension and 30 without—to assess how these elements interact during heart attacks.
What we found was quite revealing. Patients with hypertension, known as group 1, exhibited significantly higher levels of cardiac injury markers like troponin I and creatine kinase MB compared to the non-hypertensive group 2. Interestingly, group 1 also had lower levels of important antioxidant agents, including selenium, which may play a protective role during heart events.
We observed a consistent inverse relationship between selenium and the levels of myocardial injury markers in those with hypertension. This indicates that lower selenium levels are tied to more severe cardiac injury. While patients in both groups did show some correlation between antioxidant enzymes and troponin levels, it was particularly strong in the hypertensive group, hinting at a more severe impact of oxidative stress in these patients.
Overall, while our study highlights the correlations between selenium levels and cardiac injury, it does not demonstrate a clear direct benefit of selenium treatment on heart attack outcomes.
References
Chen C, Ma J, Duan S, Xue M, Yang Z, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. doi:10.1016/j.biomaterials.2025.123119
Elseweidy MM, Ali SI, Shaheen MA, Abdelghafour AM, Hammad SK. Enhancement of cardiac angiogenesis in a myocardial infarction rat model using selenium alone and in combination with PTXF: the role of Akt/HIF-1α signaling pathway. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:4677. doi:10.1007/s00210-023-02904-9
Sun Q, Yao J, Zhang Z, Li J, Zhang X, et al. Facile fabrication of biocompatible injectable blended polymeric hydrogel with bioactive nanoformulation to improving cardiac tissue regeneration efficiency after myocardial infarction for nursing care potential applications. Nanotoxicology. 2023;17:432. doi:10.1080/17435390.2023.2252921
Wang Z, Yang N, Hou Y, Li Y, Yin C, et al. L-Arginine-Loaded Gold Nanocages Ameliorate Myocardial Ischemia/Reperfusion Injury by Promoting Nitric Oxide Production and Maintaining Mitochondrial Function. Adv Sci (Weinh). 2023;10:e2302123. doi:10.1002/advs.202302123
Sun Q, Ma H, Zhang J, You B, Gong X, et al. A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction. Adv Sci (Weinh). 2023;10:e2204999. doi:10.1002/advs.202204999
Gutiérrez-Bedmar M, Gil F, Olmedo P, Ruiz-Canela M, Martínez-González MÁ, et al. Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study. J Clin Med. 2022;11. doi:10.3390/jcm11226664
Yang C, Zhu C, Li Y, Li Z, Zhang Z, et al. Injectable selenium-containing polymeric hydrogel formulation for effective treatment of myocardial infarction. Front Bioeng Biotechnol. 2022;10:912562. doi:10.3389/fbioe.2022.912562
Filonenko M, Zhuravlyova L, Sokolnikova N. CORRELATION OF CARDIAC BIOMARKERS WITH THE LEVELS OF SELENIUM AND ANTIOXIDANT ENZYMES IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND A HISTORY OF HYPERTENSION. Wiad Lek. 2022;75:362.
Frączek-Jucha M, Kabat M, Szlósarczyk B, Czubek U, Nessler J, et al. Selenium deficiency and the dynamics of changes of thyroid profile in patients with acute myocardial infarction and chronic heart failure. Kardiol Pol. 2019;77:674. doi:10.33963/KP.14822
Büttner P, Obradovic D, Wunderlich S, Feistritzer HJ, Holzwirth E, et al. Selenoprotein P in Myocardial Infarction With Cardiogenic Shock. Shock. 2020;53:58. doi:10.1097/SHK.0000000000001342
Khaki-Khatibi F, Mansouri F, Hajahmadipoorrafsanjani M, Ghojazadeh M, Gholikhani-Darbroud R. Study of rs1137101 polymorphism of leptin receptor gene with serum levels of selenium and copper in the patients of non-ST-segment elevation myocardial infarction (NSTEMI) in an Iranian population. Clin Biochem. 2018;60:64. doi:10.1016/j.clinbiochem.2018.06.016
Dallak M. A synergistic protective effect of selenium and taurine against experimentally induced myocardial infarction in rats. Arch Physiol Biochem. 2017;123:344. doi:10.1080/13813455.2017.1347687
Hu XF, Eccles KM, Chan HM. High selenium exposure lowers the odds ratios for hypertension, stroke, and myocardial infarction associated with mercury exposure among Inuit in Canada. Environ Int. 2017;102:200. doi:10.1016/j.envint.2017.03.002
Afridi HI, Kazi TG, Talpur FN, Kazi A, Arain SS, et al. Interaction between selenium and mercury in biological samples of Pakistani myocardial infarction patients at different stages as related to controls. Biol Trace Elem Res. 2014;158:143. doi:10.1007/s12011-014-9932-8
Li T, Liu X, Yang B, Wang Z, Chen Y, et al. Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy. Free Radic Biol Med. 2025;232:292. doi:10.1016/j.freeradbiomed.2025.03.004
Al-Rasheed NM, Attia HA, Mohamed RA, Al-Rasheed NM, Al-Amin MA. Preventive effects of selenium yeast, chromium picolinate, zinc sulfate and their combination on oxidative stress, inflammation, impaired angiogenesis and atherogenesis in myocardial infarction in rats. J Pharm Pharm Sci. 2013;16:848.
Siniavskiĭ IuA, Kraĭsman VA, Suleĭmenova ZhM. [Using of a specialized fermented soy milk product on the basis of soybeans in cardiology practice]. Vopr Pitan. 2013;82:51.
Ošt'ádalová I. Biological effects of selenium compounds with a particular attention to the ontogenetic development. Physiol Res. 2012;61:S19.